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A method for measuring dermal exposure to multifunctional acrylates.

J Surakka1, S Johnsson, G Rosén

  • 1National Institute for Working Life, S-112 79 Stockholm, Sweden. Jouni.Surakka@niwl.se

Journal of Environmental Monitoring : JEM
|September 1, 2001
PubMed
Summary
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A new tape-stripping method effectively measures dermal exposure to tripropylene glycol diacrylate (TPGDA), a common furniture coating allergen. This efficient, accurate, and economical technique aids in assessing occupational risks from multifunctional acrylates.

Area of Science:

  • Occupational Health and Safety
  • Dermal Toxicology
  • Analytical Chemistry

Background:

  • UV-curable acrylates, like tripropylene glycol diacrylate (TPGDA), are widely used in furniture coatings.
  • TPGDA is a known skin allergen and irritant, necessitating robust exposure assessment methods.
  • Current methods for measuring dermal exposure to such compounds are insufficient.

Purpose of the Study:

  • To develop and validate a skin and surface sampling method for assessing occupational dermal exposure to multifunctional acrylates.
  • To establish a quantitative gas chromatographic analysis method for TPGDA.
  • To identify the most effective tape for sampling TPGDA from skin and surfaces.

Main Methods:

  • Tape stripping technique was employed using twelve different adhesives to sample TPGDA and UV-coating from glass, guinea pig skin, and human volunteer skin.

Related Experiment Videos

  • Optimization of variables including applied dose, retention time, tape adhesion time, and number of strippings.
  • Gas chromatography was used for quantitative analysis of collected samples.

    • Main Results:

    • Fixomull tape demonstrated superior performance in sampling and analysis, showing consistent removal efficiencies.
    • Average removal efficiency for TPGDA from exposed skin was 85% (RSD = 14.1) with a single stripping.
    • Average removal efficiency for UV-resin was 63% (RSD = 20.2) with a single stripping.

    Conclusions:

    • The developed tape-stripping and gas chromatographic method is efficient, accurate, and economical for measuring dermal exposure to multifunctional acrylates.
    • This method provides a sensitive tool for assessing occupational skin exposure to acrylates and other surface contaminants.
    • The findings support improved safety protocols in industries utilizing UV-curable coatings.