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Regiospecific synthesis of 4-(2-oxoalkyl)pyridines
A R Katritzky1, S Zhang, T Kurz
1Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, 32611-7200, USA. katritzky@chem.ufl.edu
Organic Letters
|September 1, 2001
Abstract:
[reaction: see text]. A new and operationally simple method has been developed for the regiospecific syntheses of 4-(2-oxoalkyl)pyridines from ketones and pyridine in good yields, using triflic anhydride to activate the pyridine ring.