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Mifepristone 100 mg in abortion regimens
M D Creinin1, H C Pymar, J L Schwartz
1Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. mcreinin@mail.magee.edu
Obstetrics and Gynecology
|September 1, 2001
Summary
This study found that a low dose of mifepristone (100 mg) followed by 800 mcg of vaginal misoprostol achieved a 100% abortion rate. This regimen offers an effective alternative for early pregnancy termination.
Area of Science:
- Reproductive Medicine
- Pharmacology
Background:
- Medical abortion protocols often involve mifepristone and misoprostol.
- Optimizing dosage and administration routes is crucial for efficacy and safety.
Purpose of the Study:
- To evaluate the clinical effectiveness of a 100 mg mifepristone dose followed by misoprostol.
- To compare oral misoprostol (400 mcg) versus vaginal misoprostol (800 mcg) in early gestation (up to 49 days).
Main Methods:
- Eighty women received mifepristone 100 mg.
- Participants were randomized to receive either 400 mcg oral misoprostol or 800 mcg vaginal misoprostol 48 hours later.
- Follow-up assessments occurred at 24 hours and 2-3 weeks post-misoprostol administration.
Main Results:
- Complete abortion rates were 85% for oral misoprostol and 100% for vaginal misoprostol.
- Vaginal misoprostol showed a statistically significant higher complete abortion rate (P=.03).
- Fewer women in the vaginal misoprostol group required surgical intervention (0% vs. 10%).
Conclusions:
- A low-dose mifepristone regimen (100 mg) combined with 800 mcg vaginal misoprostol is highly effective.
- This combination presents a viable alternative to higher-dose mifepristone protocols.
- Vaginal misoprostol administration appears more effective than oral in this low-dose regimen.