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alpha-Synuclein gene haplotypes are associated with Parkinson's disease
M Farrer1, D M Maraganore, P Lockhart
1Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Human Molecular Genetics
|September 5, 2001
Abstract:
We report haplotype analysis of the alpha-synuclein gene in Parkinson's disease (PD), extending earlier reports of an association with a polymorphism within the gene promoter. This analysis showed significant differences in haplotypes between PD cases and controls. Our analyses demonstrate that genetic variability in the alpha-synuclein gene is a risk factor for the development of PD. These genetic findings are analogous to the tau haplotype over-represented in progressive supranuclear palsy and further extend the similarity in the etiologies and pathogeneses of the synucleinopathies and tauopathies.