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Accelerated atheroma, antiphospholipid antibodies, and the antiphospholipid syndrome
J George1, D Haratz, Y Shoenfeld
1Department of Cardiology, Tel Aviv Medical Center, Tel Aviv, Israel.
Rheumatic Diseases Clinics of North America
|September 6, 2001
Abstract:
Indirect data coming from animal studies and in vitro observations support the contention that the mere presence of antiphospholipid antibodies may be sufficient to increase atheroma development, regardless of other predisposing factors. It seems that humoral and cellular immune responses to beta 2-glycoprotein I can play an important role in mediating the increased propensity to atherosclerosis.