Related Experiment Videos
Treatment of alpha1-antitrypsin-deficiency panniculitis with minocycline
M Ginarte1, E Rosón, C Peteiro
1Department of Dermatology, General Hospital of Galicia, Faculty of Medicine, Santiago de Compostela, Spain. mginartev@meditex.es
Abstract:
A small proportion of patients with alpha1-antitrypsin (alpha1AT) deficiency experience recurrent ulcerating panniculitis. Studies suggest that alpha1AT-deficiency panniculitis reflects an uncontrolled inflammatory process because of the serum's incapacity to neutralize proteolytic enzymes released by leukocytes in the skin. Dapsone is considered the treatment of choice for this entity, but it is limited by its side effects, especially hematologic ones. Tetracyclines have anticollagenase and anti-inflammatory activity and have been used successfully to treat this type of panniculitis. We report the case of a 42-year-old woman with recurrent alpha1AT-deficiency panniculitis who did not tolerate the side effects of dapsone or systemic corticosteroid. Minocycline treatment led to disappearance of lesions, and long-term administration prevented recurrences without evident negative side effects. We consider minocycline a safe treatment that allows control of alpha1AT-deficiency panniculitis.
Related Concept Videos
Atypical Pneumonia
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Chronic Pancreatitis II: Collaborative Care
Assessment:
Myocarditis III: Medical Management
Acne Infection
Chronic Obstructive Pulmonary Disease II: Emphysema