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Using Intralesional Adalimumab for Chronic Refractory Cutaneous Granulomatous Inflammation
Houriah Y Nukaly1, Siddharth Srikakolapu1, Dirk M Elston1
1Dr. Nukaly is from the Division of Experimental Medicine, McGill University Health Centre, Montréal, Québec, Canada. Drs. Srikakolapu and Elston are from the Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston.
None:
Chronic localized granulomatous dermatoses present a therapeutic challenge, particularly in cosmetically sensitive areas where standard treatments often prove insufficient or intolerable. We describe a technique using intralesional injection of adalimumab to treat chronic refractory cutaneous granulomatous inflammation. This method highlights the potential of intralesional tumor necrosis factor (TNF) α inhibition as a targeted treatment option in refractory cutaneous granulomatous inflammation, offering localized efficacy while minimizing systemic exposure.
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