Related Experiment Video
Updated: Jun 18, 2026

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb
Published on: August 30, 2016
Unusually accelerated silylmethyl transfer from tin in stille coupling: implication of coordination-driven
1Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Yoshida, Kyoto 606-8501, Japan.
Abstract:
The palladium-catalyzed cross-coupling reaction of 2-PyMe2SiCH2SnBu3 with aryl iodide (Ar-I) exclusively produced the 2-PyMe2SiCH2 transferred product 2-PyMe2SiCH2Ar. The relative transfer ability of organic group from tin was found to be 2-PyMe2SiCH2 >> Ph > Me > Bu >> PhMe2SiCH2, which implies the beneficial pyridyl-to-palladium coordination effect. Thus, the transfer of the silylmethyl group from tin to palladium was remarkably accelerated by simply appending the 2-pyridyl group on silicon. The pyridyl-to-palladium coordination was validated in the palladium(II) complex 2-PyMe2SiCH2PdClPPh3 by 1H NMR and X-ray crystal structure analysis. The cross-coupling product was used for further transformations. The C-Si oxidation of the cross-coupling product 2-PyMe2SiCH2Ar afforded ArCH2OH in high yield. The fluoride ion-catalyzed 1,2-addition of 2-PyMe2SiCH2Ar to carbonyl compound (RR'C=O) gave ArCH2C(OH)RR' in high yield.
More Related Videos
Related Concept Videos
Cooperative Allosteric Transitions
Energy to Drive Translocation
Generally, polypeptides are unfolded by two distinct...
Cooperative Allosteric Transitions
Cooperative Allosteric Transitions
Transition State Theory
Transfer Function in Control Systems
To derive the transfer function, consider a general nth-order linear time-invariant...

