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Sjogren's syndrome: direct immunofluorescence in diagnosis
1Oral Pathology Service, First Department of Odontostomatology, Second University of Naples Medical School, Naples, Italy.
Background:
Sjogren's syndrome (SS) is an autoimmune inflammatory exocrinopathy. In the classical clinical presentation, diagnosis is readily achieved but this is less easy in early disease or oligosymptomatic forms.
Methods:
We have used direct immunofluorescence (d.i.f.), with IgG antibodies, comparing salivary gland biopsies from subjects with SS compared with control subjects.
Results:
Direct immunofluorescence, using antibodies anti-IgG and demonstrating positivity for all the examined champions of SS while it is negative for control biopsies.
Conclusions:
Direct immunofluorescence, on salivary glands by biopsy, can be considered a valid additional aid to the diagnosis of subclinical SS.