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Oligomerization of deoxynucleoside-bisphosphate dimers: template and linkage specificity
J Visscher1, R van der Woerd, C G Bakker
1Laboratory for Exobiology, University of Nijmegen, The Netherlands.
Abstract:
Evidence is presented that a poly(U) template selectively favors the oligomerization of the activated, 3'-5' pyrophosphate-linked dimer pdAppdAp, in comparison with the 3'-3' and 5'-5' linked dimers. In the absence of poly(U), the 5'-5' linked dimer is the most reactive, and chains are formed which are more than 60 monomer units in length.