Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emergence of template-and-sequence-directed (TSD) syntheses: II. A computer simulation model.

S Nir1, N Lahav

  • 1The Hebrew University of Jerusalem, The Seagram Center for Soil and Water Sciences, Rehovot, Israel.

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
|September 7, 2001
PubMed
Summary

This study models peptide-catalyzed oligomeric growth, showing how proto-RNA and peptides can self-replicate and catalyze reactions, crucial for the origin of life.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On the mass dependence of diffusion within biological membranes and polymers.

The Journal of membrane biology·2013
Same author

Number of retrieved lymph nodes and survival in node-negative patients undergoing laparoscopic colorectal surgery for cancer.

Techniques in coloproctology·2010
Same author

Evidence for pre-zygotic reproductive barrier between the B and Q biotypes of Bemisia tabaci (Hemiptera: Aleyrodidae).

Bulletin of entomological research·2010
Same author

Kinetics of influenza virus fusion with the endosomal and plasma membranes of cultured cells. Effect of temperature.

The Journal of membrane biology·2003
Same author

Organo-clay formulation of acetochlor for reduced movement in soil.

Journal of agricultural and food chemistry·2001
Same author

Kinetic analysis of the initial steps involved in lipoplex--cell interactions: effect of various factors that influence transfection activity.

Biochimica et biophysica acta·2001

Area of Science:

  • Origin of Life Research
  • Computational Biology
  • Biochemistry

Background:

  • The origin of life requires self-replicating molecules and catalytic systems.
  • Previous work established a bio-geochemical scenario for early Earth.

Purpose of the Study:

  • To computer model peptide-catalyzed oligomeric growth as a central mechanism in the origin of life.
  • To investigate the emergence of self-replicating proto-RNA and catalytic peptides from basic building blocks.

Main Methods:

  • Utilized a computer model based on mass action equations for peptide-catalyzed oligomeric growth.
  • Simulated a minimal system with proto-RNA templates, peptides, and their building blocks.
  • Incorporated assumptions for proto-RNA replication and molecular selectivity.

Related Experiment Videos

Main Results:

  • The model demonstrated rapid increases in proto-transfer RNA (proto-tRNA) proportions.
  • Autocatalytic cycles emerged, leading to the accumulation of catalytic peptides and proto-tRNAs.
  • The system showed robustness across various reaction parameters and initial concentrations.

Conclusions:

  • The model successfully describes the buildup of a molecular mechanism for initiating a minimal template-directed synthesis (TSD) reaction cycle.
  • This TSD reaction cycle is proposed as central to the origin of life due to its biological significance.
  • The robustness of the 'toy model' supports its relevance to molecular evolution.