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Updated: Aug 13, 2026

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
Published on: January 31, 2018
Heavy ion-induced chromosomal damage and repair
1Cell and Molecular Biology Division, Lawrence Berkeley Laboratory, University of California, Berkeley 94720, USA.
Abstract:
We have been using the "premature chromosome condensation (PCC)" technique to investigate chromosomal breakage, rejoining and misrepair induced by accelerated heavy ions. With the presentation of new Fe experiments, we now review the available PCC data to summarize our current understanding of the action of high velocity charged particles on mammalian chromosomes. Implications for the survival RBE/LET relationship are also discussed.
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