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The evolving microlesion concept.

P Todd1

  • 1Bioprocessing and Pharmaceutical Research Center, Philadelphia, PA 19104, USA.

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
|January 1, 1986
PubMed
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The microlesion concept in carcinogenesis was explored using quantitative data. Tumor induction action cross sections varied significantly between cultured cells and mouse Harderian glands, suggesting biological differences.

Area of Science:

  • Radiation biology
  • Carcinogenesis research
  • Space biology

Background:

  • The microlesion concept, proposed in the 1970s, suggests that radiation-induced damage to cells can initiate cancer.
  • Quantitative carcinogenesis data from laboratory experiments are crucial for understanding radiation effects.

Purpose of the Study:

  • To explore the microlesion concept using published quantitative carcinogenesis data.
  • To compare the carcinogenic sensitivity of in vitro cultured cells and in vivo mouse Harderian gland cells exposed to iron ion radiation.

Main Methods:

  • Utilized published quantitative carcinogenesis data from laboratory experiments.
  • Interpreted experimental data using track calculations.
  • Employed data from studies using the Fe ion beam at the Lawrence Berkeley Laboratory Bevalac.

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Main Results:

  • The action cross section for tumor induction in cultured cells was found to be approximately 0.032 micrometer2.
  • The action cross section for tumor induction in mouse Harderian gland cells was approximately 1/1000th that of cultured cells.
  • A significant difference in carcinogenic sensitivity was observed between the two biological systems.

Conclusions:

  • The substantial difference in carcinogenic sensitivity reflects underlying biological disparities between cultured cells and mouse Harderian gland cells.
  • These findings highlight the complexity of radiation carcinogenesis.
  • The quantitative applicability of these mouse models to humans in space remains uncertain.