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Related Experiment Videos

Early development in the mouse: would it be affected by microgravity?

E Lehtonen1, M H Snow

  • 1Department of Pathology, University of Helsinki, Finland.

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
|January 1, 1989
PubMed
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Gravity may influence mammalian embryonic development, similar to amphibians and birds. This study examines key mouse embryogenesis events, like axis formation and implantation, to assess gravity's potential role as a morphogenetic signal.

Area of Science:

  • Developmental Biology
  • Embryology
  • Gravitational Biology

Background:

  • Gravity is a known morphogenetic signal in amphibian and bird development.
  • Mammalian embryogenesis presents unique developmental stages compared to other vertebrates.
  • Understanding gravity's role in mammalian development is crucial for comparative biology.

Purpose of the Study:

  • To investigate the potential role of gravity as a morphogenetic signal in mammalian embryonic development.
  • To identify key events in mouse embryogenesis where polarity is critical and gravity may be a factor.
  • To assess the experimental data concerning gravity's involvement in mammalian developmental processes.

Main Methods:

  • Review of mouse embryogenesis, focusing on polarity establishment.

Related Experiment Videos

  • Analysis of developmental events including compaction, axis formation, implantation, and rotation.
  • Discussion of existing experimental data on these morphogenetic steps.

    • Main Results:

    • Identified key polarity-dependent events in mouse embryogenesis: cleavage, axis establishment (radial, embryonic-abembryonic, dorso-ventral, anterior-posterior), implantation, and rotation.
    • Highlighted differences in mammalian development that warrant investigation into gravity's influence.
    • Prepared for assessment of experimental data on gravity's potential causative role.

    Conclusions:

    • Gravity is a plausible morphogenetic signal in mammalian embryonic development.
    • Further experimental data is needed to confirm gravity's causative role in specific mammalian developmental events.
    • Comparative analysis suggests gravity's influence may be conserved across vertebrate development.