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The microlesion concept in HZE particle dosimetry
1Althouse Laboratory, University Park, PA 16802, USA.
Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
|January 1, 1984
Summary
High-Z (HZE) particle radiation, primarily iron nuclei, creates microlesions in cells. This study investigates microlesions as a unit for assessing radiation hazards to astronauts.
Area of Science:
- Space radiation biology
- High-energy particle physics
- Radiation toxicology
Background:
- High-energy, high-Z (HZE) particles, predominantly iron nuclei, pose a radiation risk in space.
- These particles cause cellular damage along their tracks, termed microlesions.
Purpose of the Study:
- To define conditions for microlesion formation in specific tissues.
- To find biological evidence of microlesion production.
- To evaluate microlesions as a dose unit for assessing astronaut radiation hazards.
Main Methods:
- Analysis of microlesion formation in individual cells and hair follicles.
- Microbial studies to investigate secondary electron action.
- Evaluation of Fe particle irradiation effects on mouse Harderian glands.
Main Results:
- Microlesions have been observed in individual cells and hair follicles.
- Microbial studies suggest independent secondary electron action.
- Fe particle irradiation efficiently induces tumors in mouse Harderian glands.
Conclusions:
- Microlesions are a significant biological effect of HZE particle radiation.
- The damaging potential of microlesions depends on the affected tissues.
- Further research is needed to establish microlesions as a standard unit for HZE radiation hazard assessment.