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Related Experiment Videos

Helium-ion-induced human cataractogenesis.

E A Blakely1, I K Daftari, W J Meecham

  • 1Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA.

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
|October 1, 1994
PubMed
Summary
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Helium ion therapy for intraocular melanoma can cause cataracts due to incidental lens exposure. This study examines dose-response data to understand cataract risk, relevant for space flight radiation exposure.

Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Medical Physics

Background:

  • Intraocular melanoma treatment with helium ions carries a risk of radiation-induced cataracts.
  • Incidental lens exposure is often unavoidable during treatment of posterior intraocular tumors.
  • Accurate dose assessment is crucial for understanding treatment complications.

Purpose of the Study:

  • To analyze the exposure-response relationship for helium ion radiation and human cataract development.
  • To report preliminary findings on lens opacifications and cataracts in patients treated with helium ions.
  • To inform risk assessment for cataract development from radiation exposure, including space flight.

Main Methods:

  • Retrospective analysis of clinical records from 347 primary intraocular melanoma patients treated with helium ions.
Keywords:
NASA Discipline Number 93-10NASA Discipline Radiation HealthNASA Program NSCORTNon-NASA Center

Related Experiment Videos

  • Quantitative assessment of individual lenticular radiation dose and radiation quality.
  • Evaluation of cataract development in 54 patients with limited lens involvement (≤10% of lens in treatment field).

    • Main Results:

    • Preliminary results show the development of helium-ion-induced lens opacifications and cataracts in a subset of patients.
    • The study focuses on patients with minimal lens exposure, providing insights into low-dose effects.
    • Dose-response data is being collected for further analysis.

    Conclusions:

    • Helium ion therapy for intraocular melanoma can lead to cataract formation.
    • Understanding the dose-response relationship is critical for managing treatment risks.
    • Findings may contribute to estimating cataract risk from radiation exposure in space flight environments.