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Diuretic as a means for rapid adaptation to weightlessness
1Institute of Biomedical Problems, Moscow, Russia.
Acta Astronautica
|December 1, 1994
Summary
Spaceflight causes discomfort due to fluid shifts. A diuretic, lasix, was used to induce controlled hypohydration, successfully reducing discomfort and improving cosmonauts' work capacity in microgravity.
Area of Science:
- Space Medicine
- Human Physiology in Space
- Pharmacology
Background:
- Spaceflight astronauts and cosmonauts often experience health issues in microgravity.
- Fluid shifts towards the head are a primary cause of discomfort during initial space flight.
- Developing countermeasures for space adaptation syndrome is crucial for crewed missions.
Purpose of the Study:
- To investigate controlled hypohydration using a diuretic as a countermeasure for spaceflight-induced discomfort.
- To assess the feasibility of managing adaptation to microgravity through fluid manipulation.
- To evaluate the impact of lasix on cosmonaut well-being and performance.
Main Methods:
- Six cosmonauts received a daily dose of lasix during the first three days of their space mission.
- Data collection included correction tests, questionnaires, and hematocrit measurements.
- Experiment data was logged and transmitted to a control center for analysis.
Main Results:
- The diuretic (lasix) effectively reduced feelings of discomfort and improved the general condition of cosmonauts.
- Objective correction tests indicated enhanced work ability among the cosmonauts.
- Circulating plasma volumes were reduced by an average of 6.8% following hypohydration.
Conclusions:
- Controlled hypohydration with lasix is a feasible countermeasure against negative spaceflight adaptation effects.
- Diuretic administration can alleviate discomfort and improve cosmonaut performance in microgravity.
- Fluid volume management is a key factor in optimizing crew health and mission success.
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