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Respective effects of hindlimb suspension, confinement and spaceflight on myotendinous junction ultrastructure
A J Zamora1, A Carnino, S Roffino
1I.C.N.E. CNRS, UMR 9941, Faculte de Medecine Nord, Marseille.
Abstract:
This study compares the effects of 14-day confinement and spaceflight with the respective effects of 8, 18 and 29-day hindlimb suspension on rat soleus and plantaris MTJ ultrastructure. Independently of the experimental situation, greater morphological changes were observed in the soleus as compared to the plantaris MTJ. 18 days of suspension and 14 days of confinement resulted in ultrastructural modifications of the digit-like processes in the soleus MTJ. Additional changes were observed in the myofibrils, microtendon and tendon after 29 days of suspension and 4 days of spaceflight. These results emphasize the influence of the intensity and duration of the muscle loading on the MTJ ultrastructure.