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Skeletal alterations in rats during space flight.

T J Wronski1, E Morey-Holton, W S Jee

  • 1NASA-Ames Research Center, Mountain View, CA, USA.

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
|January 1, 1981
PubMed
Summary

Spaceflight reduced bone formation and decreased bone volume in rats. Bone marrow fat content increased, indicating significant skeletal changes during the Cosmos 1129 mission.

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Area of Science:

  • Space biology
  • Skeletal physiology
  • Gravitational biology

Background:

  • Understanding the effects of microgravity on bone health is crucial for long-duration space missions.
  • Previous studies have indicated potential negative impacts of spaceflight on bone metabolism.

Purpose of the Study:

  • To investigate the skeletal adaptations of male Wistar rats during an 18.5-day space flight mission aboard Cosmos 1129.
  • To quantify changes in bone formation, bone volume, and bone marrow composition.

Main Methods:

  • Male Wistar rats were housed on the Cosmos 1129 biological satellite for 18.5 days.
  • Skeletal parameters including periosteal bone formation, trabecular bone volume, and bone marrow fat content were analyzed.

Main Results:

  • A reduced rate of periosteal bone formation was observed in the tibial and humeral diaphyses.
  • Decreased trabecular bone volume was noted in the rat skeletons.
  • An increased fat content in the bone marrow of the proximal tibial metaphysis was evident.

Conclusions:

  • Spaceflight induces significant skeletal alterations in rats, including impaired bone formation and reduced bone density.
  • These findings highlight the detrimental effects of microgravity on bone health and the need for countermeasures.
Keywords:
NASA Experiment Number COS 1129-9

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