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Updated: Jun 26, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Redesigning nucleic acids
S A Benner1, T R Battersby, B Eschgfaller
1Department of Chemistry, University of Florida, Gainesville 32611, USA.
Abstract:
A research program has applied the tools of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides to learn more about the chemical principles underlying their ability to store and transmit genetic information. Oligonucleotides (as opposed to nucleosides) have long been overlooked by synthetic organic chemists as targets for structural modification. Synthetic chemistry has now yielded oligonucleotides with 12 replicatable letters, modified backbones, and new insight into why Nature chose the oligonucleotide structures that she did.
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