Changes in body fluid distribution during 7 days 6 degrees head-down bed rest

It is well known that, in a state of weightlessness, body fluids shift toward the head site, but the actual rates of the migration of fluids has never been measured. In order to identify the causes of reduced orthostatic tolerance and the reduction in circulating blood volume after returning from a space mission, it is necessary to measure the changes in body fluid distribution. Although the methods for measuring changes in body fluids include the use of isotopes or pigments, such methods cannot be employed in space due to their invasive properties. Therefore, we directed our attention toward the impedance method, for which we developed a non-invasive apparatus for measuring the distribution of body fluids. We therefore measured the actual distribution of body fluids using the bed-rest method, a model of the zero gravity state.