Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiological changes in spaceflight that may affect drug action.

T R Czarnik1, J Vernikos

  • 1WSU Aerospace Medicine, Dayton, OH.

Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology
|September 7, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The therapeutic benefits of gravity in space and on earth.

Hippokratia·2008
Same author

Human exploration of space: why, where, what for?

Hippokratia·2008
Same author

From space to Earth: advances in human physiology from 20 years of bed rest studies (1986-2006).

European journal of applied physiology·2007
Same author

Blood pressure changes during orthostatic stress: evidence of gender differences in neuroeffector distribution.

Aviation, space, and environmental medicine·2001
Same author

The International Space Life Sciences Working Group.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2001
Same author

Dietary salt and urinary calcium excretion in a human bed rest spaceflight model.

Aviation, space, and environmental medicine·2000
Same journal

Hypergravity effects on pregnancy and parturition.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2013
Same journal

Characteristics of the parallel-plate flow chamber for mechanical stimulation of bone cells under microgravity.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2009
Same journal

From the first dog to the last monkey in space.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2008
Same journal

Columbus, the European Physiology Modules Facility and CADMOS.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2008
Same journal

Abdominal and fetal echography tele-operated in several medical centres sites, from an expert center, using a robotic arm & telephone or satellite link.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2008
Same journal

WISE-2005: developing a non-invasive method to monitor cardiovascular deconditioning.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2008
See all related articles

Pharmacology in microgravity remains understudied. This review explores how spaceflight affects drug pharmacokinetics and pharmacodynamics, highlighting the need for more research on long-duration missions.

Area of Science:

  • Space Medicine
  • Pharmacology
  • Physiology

Background:

  • Limited research exists on drug effects during spaceflight.
  • Studies often focus on early spaceflight or bed rest simulations.
  • Physiological changes during spaceflight are dynamic and impact drug action.

Purpose of the Study:

  • To review how microgravity affects drug pharmacokinetics and pharmacodynamics.
  • To highlight the need for more research on long-duration space missions.
  • To examine drug absorption, distribution, metabolism, and excretion in space.

Main Methods:

  • Review of existing literature on microgravity and drug effects.
  • Analysis of pharmacokinetic parameters (absorption, distribution, metabolism, excretion).

Related Experiment Videos

  • Discussion of physiological factors influencing drug action in space.

    • Main Results:

    • Microgravity is hypothesized to alter pharmacokinetics and pharmacodynamics.
    • Drug absorption and distribution may be significantly affected by spaceflight.
    • More research is needed to understand long-term spaceflight effects on drug efficacy.

    Conclusions:

    • Spaceflight significantly impacts drug behavior in the human body.
    • Altered pharmacokinetics and pharmacodynamics require further investigation.
    • Understanding these changes is crucial for astronaut health and safety.