Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone ultrastructural changes in Bion 11 rhesus monkeys.

N V Rodionova1, I M Shevel, V S Oganov

  • 1Schmalhauzen Institute of Zoology, Ukrainian Academy of Sciences, Kiev, Ukraine.

Journal of Gravitational Physiology : a Journal of the International Society for Gravitational Physiology
|September 7, 2001
PubMed
Summary

Spaceflight significantly reduced bone formation in Bion 11 monkeys. Electron microscopy revealed inactive osteoblasts and impaired bone mineralization, indicating decreased osteogenesis during the mission.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combined Preconditioning Reduces the Negative Influence of Cerebral Ischemia on the Morphofunctional Condition of CNS.

Bulletin of experimental biology and medicine·2021
Same author

[Erythropoietin and vascular endothelial growth factor level in normoxia and in cerebral ischemia under pharmacological and hypoxic preconditioning].

Biomeditsinskaia khimiia·2020
Same author

[INFLUENCE OF COMBINED PHARMACOLOGICAL AND HYPOXIC PRECONDITIONING ON ANIMAL SURVIVAL AND FUNCTIONAL ACTIVITY OF CNS DURING MODEL CEREBRAL ISCHEMIA.]

Eksperimental'naia i klinicheskaia farmakologiia·2018
Same author

[Experience in using Prolia in patients with postmenopausal osteoporosis in clinical practice].

Terapevticheskii arkhiv·2018
Same author

Signal Mechanism of the Protective Effect of Combined Preconditioning by Amtizole and Moderate Hypoxia.

Bulletin of experimental biology and medicine·2018
Same author

Neuroprotective Effect of Antioxidants and Moderate Hypoxia as Combined Preconditioning in Cerebral Ischemia.

Bulletin of experimental biology and medicine·2016

Area of Science:

  • Space biology
  • Bone biology
  • Cell biology

Background:

  • Understanding the effects of spaceflight on bone health is crucial for astronaut safety.
  • Previous studies have indicated potential negative impacts of microgravity on skeletal tissues.

Purpose of the Study:

  • To investigate the cellular and ultrastructural changes in bone following spaceflight.
  • To assess the impact of the Bion 11 mission on osteoblast activity and bone formation.

Main Methods:

  • Electron microscopy was used to examine iliac crest bone biopsies from Bion 11 monkeys.
  • Analysis focused on osteoblast morphology, endoplasmic reticulum, and Golgi complex structure.

Main Results:

  • A high prevalence of inactive osteoblasts was observed in flight samples.

Related Experiment Videos

  • Ultrastructural alterations in the rough endoplasmic reticulum and Golgi complex suggested reduced protein synthesis.
  • Osteogenesis declined, osteoid mineralization was altered, and fibrotic zones developed in the flight group.

    • Conclusions:

    • Spaceflight profoundly inhibits osteoblast activity and impairs bone formation.
    • The observed cellular changes indicate a significant negative impact on skeletal maintenance and repair mechanisms.
    • Further research is needed to develop countermeasures against spaceflight-induced bone loss.