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Updated: Feb 10, 2026

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
Published on: May 4, 2015
[INFLUENCE OF COMBINED PHARMACOLOGICAL AND HYPOXIC PRECONDITIONING ON ANIMAL SURVIVAL AND FUNCTIONAL ACTIVITY OF CNS
Abstract:
The combined action of amthizole administration and hypoxia conditions on the survival of rats and the functional state of the central nervous system has been studied on a model of bilateral common carotid artery occlusion. It is established that this combined preconditioning produces cerebroprotective action, increases animal survival after surgery (estimated 72 h upon the onset of ischemia) by 38% (p = 0.029) in early and by 29% (p = 0.078) in late period of the ischemia modeling, reduces neurological deficiency by 55% (p = 0.006) in early and by 43 % (p = 0.028) in late period of the ischemia modeling, and decreases severity of behavioral changes in rats caused by cerebral ischemia in both periods of ischemia modeling.
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