Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glial diffusion barriers during aging and pathological states.

E Syková1

  • 1Department of Neuroscience, 2nd Medical Faculty, Charles University, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídenská 1083, 14220 Prague 4, Czech Republic. sykova@biomed.cas.cz

Progress in Brain Research
|September 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Use of cultured human autologous bone marrow stem cells in repair of a rotator cuff tear: preliminary results of a safety study].

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2015
Same author

Stem cells regenerative properties on new rat spinal fusion model.

Physiological research·2014
Same author

Both autologous bone marrow mononuclear cell and peripheral blood progenitor cell therapies similarly improve ischaemia in patients with diabetic foot in comparison with control treatment.

Diabetes/metabolism research and reviews·2013
Same author

Experimental reconstruction of the injured spinal cord.

Advances and technical standards in neurosurgery·2011
Same author

[Treatment of critical limb ischemia and diabetic foot disease by the use of autologous stem cells].

Vnitrni lekarstvi·2011
Same author

The diffusion parameters of the extracellular space are altered in focal cortical dysplasias.

Neuroscience letters·2011
Same journal

Preface.

Progress in brain research·2025
Same journal

Mindfulness and meditation: Promoting emotional and cognitive health.

Progress in brain research·2025
Same journal

Cognitive stimulation enhancing memory and mental function.

Progress in brain research·2025
Same journal

The science behind non-pharmacological interventions.

Progress in brain research·2025
Same journal

Technology-assisted interventions for neuropsychiatric disorders.

Progress in brain research·2025
Same journal

Ethical consideration in non-pharmacological treatments for neuropsychiatric disorders.

Progress in brain research·2025
See all related articles

Glial cells regulate the brain's extracellular space (ECS) volume and ion balance, influencing neuronal communication and synchronization. These cells impact synaptic transmission, plasticity, and memory formation through their control over ECS architecture.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Glial Cell Biology

Background:

  • The extracellular space (ECS) in the central nervous system (CNS) is crucial for modulating synaptic and extrasynaptic signal transmission.
  • Glial cells, particularly astrocytes, play a significant role in regulating the ECS's ionic composition, volume, and geometry.

Purpose of the Study:

  • To elucidate the mechanisms by which glial cells influence ECS properties and consequently affect neuronal communication.
  • To explore the role of glial-mediated ECS changes in synaptic transmission, plasticity, and behavior.

Main Methods:

  • The study discusses proposed models linking ionic and volume changes in the ECS to neuronal activity.
  • It reviews evidence on glial cell swelling, hypertrophy, and proliferation impacting ECS tortuosity and diffusion.

Related Experiment Videos

  • The role of extracellular matrix molecules like proteoglycans and fibronectin in ECS diffusion is considered.

    • Main Results:

    • Neuronal activity leads to [K+]e accumulation, glial depolarization, and acid extrusion, decreasing neuronal excitability.
    • Glial swelling and ECS volume shrinkage amplify this feedback mechanism, increasing diffusion hindrance for neuroactive substances.
    • Astrocyte morphology and extracellular matrix components influence ECS diffusion anisotropy, affecting extrasynaptic transmission and synaptic 'cross-talk'.

    Conclusions:

    • Glial cells are key regulators of CNS local architecture, significantly impacting signal transmission, synaptic plasticity (LTP/LTD), and memory formation.
    • Changes in ECS properties mediated by glial cells can modulate neuronal interactions, synchronization, and neuron-glia communication.
    • The interplay between glial cells, ECS characteristics, and extracellular matrix molecules is fundamental to brain function and behavior.