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Imaging posterior polymorphous corneal dystrophy by in vivo confocal microscopy
C N Grupcheva1, G S Chew, M Edwards
1Discipline of Ophthalmology, University of Auckland, New Zealand. c.mcghee@aukland.ac.nz
Clinical & Experimental Ophthalmology
|September 8, 2001
Summary
In vivo confocal microscopy effectively identified characteristic lesions of posterior polymorphous dystrophy (PPMD). This advanced imaging technique aids in diagnosing subtle corneal dystrophies like PPMD.
Area of Science:
- Ophthalmology
- Corneal Imaging
- Microscopy
Background:
- Posterior polymorphous dystrophy (PPMD) is a rare, inherited corneal dystrophy.
- Accurate diagnosis and monitoring of PPMD can be challenging due to subtle clinical presentations.
Observation:
- This study utilized slit-lamp biomicroscopy and slit-scanning in vivo confocal microscopy to examine the cornea of a female patient with PPMD.
- In vivo confocal microscopy allowed for detailed visualization of corneal structures.
Findings:
- Characteristic endothelial vesicular and band lesions of PPMD were clearly identified using in vivo confocal microscopy.
- Additional findings delineated included endothelial pleomorphism, increased density and reflectance of posterior stromal keratocytes, and prominent corneal nerves.
Implications:
- In vivo confocal microscopy significantly enhances the clinicopathological diagnosis of corneal dystrophies.
- This imaging modality is valuable for the follow-up of conditions like PPMD with subtle clinical features.