Related Experiment Video
Updated: Jul 31, 2026
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Optical coherence tomography demonstrates subretinal macular edema from papilledema
V J Hoye1, A M Berrocal, T R Hedges
1Department of Ophthalmology, Tufts University School of Medicine, Boston, MA, USA.
Papilledema associated with increased intracranial pressure can cause subretinal fluid in the macula, leading to vision loss. Optical coherence tomography (OCT) effectively detects this fluid and monitors recovery.
Area of Science:
- Ophthalmology
- Neurology
Background:
- Papilledema, a sign of increased intracranial pressure, can lead to visual disturbances.
- The macula is crucial for central vision, and its involvement can significantly impact visual acuity.
Observation:
- Optical coherence tomography (OCT) was used to examine macular changes in patients with papilledema.
- Nineteen patients with acute, subacute, or recurrent papilledema underwent detailed macular OCT analysis.
Findings:
- Subretinal fluid involving the macula was identified in seven patients using OCT.
- This fluid accumulation correlated with reduced visual acuity, originating from the peripapillary region.
- Resolution of subretinal fluid led to improved central vision.
Implications:
- Subretinal fluid is a significant cause of decreased visual acuity in papilledema.
- OCT is a valuable tool for diagnosing subretinal fluid and tracking visual recovery in papilledema patients.
More Related Videos
07:18Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
Published on: February 18, 2022
10:14Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023