[Ultrastructural changes in organelles of the dog cerebral cortex astrocytes in post-ischemic period (morphometric...

Morphometric analysis of volume density of mitochondria, rough endoplasmic reticulum (RER), Golgi complex, vacuoles, lysosomes, fibrils, superficial density of mitochondria and RER, postischemic mitochondria/RER superficial and volume ratio and astrocyte ultrastructure was carried out experimentally in dogs. The findings obtained indicate that in early postischemic period (5-10 min-3-7 d) changes in astrocyte were reactive, although since the second wk of postischemic period metabolic processes in astrocytes were disturbed, which were manifested through structural changes maximally pronounced on d 14-21 of reparative period. At late reparative period (first-third month) astrocyte structure was normalised to significant extent.