[Reorganization of the mineral matrix of the bone tissue]

Basing on experimental and clinical chronobiological investigations with an application of three different methods of estimation of osseous tissue mineral density: biochemical (phosphates content in bone tissue mineral matrix), roentgenographic densitometry and dual photon X-ray absorption, it has been shown that 4.5% of mineral matrix mass are in constant interchange with body fluids. It corresponds to the degree of fluctuations of osseous tissue mineral density (in the direction of increase or decrease) both locally and in the skeleton on the whole during the period of time amounting to about one week. This fact should be taken into consideration while evaluating the effect of drug therapy in patients with osteoporosis.