[THE MODIFICATION OF THE METHOD OF NATURAL PERIODIZATION OF BIOLOGICAL PROCESSES]

Area of Science:

• Chronobiology
• Biomedical Research
• Physiology

Background:

• The method of natural periodization is used to analyze biological processes.
• The original method coordinates parameters based on their average values over the observation period.

Purpose of the Study:

• To propose a new variant of natural periodization that coordinates parameters with control values.
• To compare the original and modified methods in analyzing biological data.
• To evaluate the dynamics of morphological parameters in the adrenal medulla after laser damage.

Main Methods:

• A modified natural periodization method coordinating parameters with control values.
• Application of both original and modified methods to analyze two-month dynamics of 19 morphological parameters.
• Study focused on the adrenal medulla part surviving laser damage.

Main Results:

• Three natural periods of adrenal medulla structure remodeling were identified.
• The original method highlighted nodal points, while the modified method better reflected overall change trends.
• Both methods are complementary, with combined use improving experimental study efficiency.

Conclusions:

• The proposed modification of natural periodization, using control values, offers a more logical approach for experimental studies.
• The combined application of both method variants enhances the analysis of biological process dynamics.
• The study successfully identified and functionally interpreted three remodeling periods in the adrenal medulla post-laser damage.