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[THE MODIFICATION OF THE METHOD OF NATURAL PERIODIZATION OF BIOLOGICAL PROCESSES].

K G Kemoklidze

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    Summary
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    A refined method for analyzing biological rhythms uses control values instead of averages for parameter coordination. This approach enhances the study of adrenal medulla remodeling after laser damage, revealing three distinct remodeling periods.

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    Area of Science:

    • Chronobiology
    • Biomedical Research
    • Physiology

    Background:

    • The method of natural periodization is used to analyze biological processes.
    • The original method coordinates parameters based on their average values over the observation period.

    Purpose of the Study:

    • To propose a new variant of natural periodization that coordinates parameters with control values.
    • To compare the original and modified methods in analyzing biological data.
    • To evaluate the dynamics of morphological parameters in the adrenal medulla after laser damage.

    Main Methods:

    • A modified natural periodization method coordinating parameters with control values.
    • Application of both original and modified methods to analyze two-month dynamics of 19 morphological parameters.
  • Study focused on the adrenal medulla part surviving laser damage.
  • Main Results:

    • Three natural periods of adrenal medulla structure remodeling were identified.
    • The original method highlighted nodal points, while the modified method better reflected overall change trends.
    • Both methods are complementary, with combined use improving experimental study efficiency.

    Conclusions:

    • The proposed modification of natural periodization, using control values, offers a more logical approach for experimental studies.
    • The combined application of both method variants enhances the analysis of biological process dynamics.
    • The study successfully identified and functionally interpreted three remodeling periods in the adrenal medulla post-laser damage.