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Dependence of pathogenic properties of leptospires on animal subspecies
Abstract:
1. Leptospires of mozdok serotype of the Pomona serogroup possessed specific pathogenic properties for a definite subspecies of Apodemus agrarius. They caused carriership in rodents of a European population, but were unable to cause such a process in Far East mice. However, leptospires of monjakov and pomona types were also unable to provoke leptospiruria in these small mammals. 2. The intensity of the formation of antibody to leptospires in different subspecies of Apodemus agrarius was dependent on the degree of their susceptibility, determined by the presence of renal leptospirosis. Leptospira-carriers among animals reacted by antibody formation 6-40 times more intensive than in those not susceptible to the infection. 3. Leptospires of pomona, monjakov and mozdok serotypes of the Pomona group taxonomically can be designated as separate subspecies, on the basis of differences in biological properties as related to their natural animal reservoirs.
Insights
Different Leptospira serotypes show varied pathogenicity in Apodemus agrarius rodents. Susceptibility to renal leptospirosis influences antibody response, suggesting distinct subspecies classification for these Leptospira types.
Area of Science:
- Veterinary Microbiology
- Zoonotic Diseases
- Rodent Ecology
Background:
- Leptospirosis is a significant zoonotic disease transmitted by various Leptospira serovars.
- Apodemus agrarius rodents are known reservoirs for several pathogens, including Leptospira.
- Understanding host-pathogen interactions is crucial for disease control and prevention.
Purpose of the Study:
- To investigate the pathogenic properties of specific Leptospira serotypes (mozdok, monjakov, pomona) within the Pomona serogroup.
- To determine the susceptibility of different Apodemus agrarius subspecies to Leptospira infection and carriership.
- To analyze the correlation between host susceptibility and antibody formation intensity in response to Leptospira.
Main Methods:
- Experimental inoculation of Apodemus agrarius subspecies with specific Leptospira serotypes.
- Monitoring for the development of leptospiruria (persistent Leptospira shedding in urine).
- Quantifying antibody titers in infected and non-infected rodents to assess immune response.
Main Results:
- Leptospira mozdok serotype induced carriership in European Apodemus agrarius but not in Far East mice.
- Monjakov and pomona types failed to induce leptospiruria in Far East mice.
- Rodents susceptible to renal leptospirosis exhibited significantly higher antibody formation (6-40 times) compared to non-susceptible individuals.
Conclusions:
- Pathogenicity of Leptospira serotypes varies among Apodemus agrarius subspecies, impacting disease transmission dynamics.
- Host susceptibility, indicated by renal leptospirosis, directly correlates with the intensity of antibody response.
- Biological and epidemiological differences support the taxonomic classification of pomona, monjakov, and mozdok serotypes as distinct subspecies within the Pomona group.