Related Experiment Videos
G-quadruplex DNA binding by a series of carbocyanine dyes
1Division of Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, 78712, USA. skerwin@mail.utexas.edu
Bioorganic & Medicinal Chemistry Letters
|September 11, 2001
Abstract:
We have examined a number of carbocyanine dyes for their ability to bind intramolecular G-quadruplex DNA structures (G4'-DNA) using a Taq polymerase stop assay. Of the five dyes examined, only one, N,N'-diethylthiacarbocyanine iodide (DTC), was found to bind to G4'-DNA. DTC was also the only dye found to inhibit human telomerase at 50 microM concentration.