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Updated: Oct 4, 2026

A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
Published on: April 11, 2014
Individual sensitivity to genotoxic effects of nickel and antimutagenic activity of ascorbic acid
I N Perminova1, T A Sinel'shchikova, N I Alekhina
1Group of Medical Ecological Studies, Institute of Industrial Ecology Problems of the North, Karelian Research Center, Russian Academy of Sciences, Apatity.
Abstract:
Cytotoxicity of nickel compounds was studied by stimulating the repair synthesis of DNA and counting lymphocyte micronuclei in workers of smelting shop of copper-nickel sulfide processing plant. Nickel content in the organism was evaluated by its concentrations in hair. Therapy with ascorbic acid (1 g/day for 1 month) led to a significant decrease in the number of micronuclei. The number of micronuclei before and after ascorbic acid treatment varied within a wide range in different individuals.
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