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Antiinflammatory effect of russian-made budesonide in experimental noninfectious pulmonary granulomatosis

A S Sladkopevtsev1, L P Mikhailova, O V Makarova

  • 1Laboratory of Inflammation Immunomorphology, Institute of Human Morphology, Russian Academy of Medical Sciences.

Bulletin of Experimental Biology and Medicine
|September 11, 2001
PubMed

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...