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Dynamics of chromosomal aberrations in male mice of various strains during aging
S V Rozenfel'd1, E F Togo, V S Mikheev
1Department of Biology and Genetics, I. P. Pavlov St. Petersburg State Medical University. biology@spmu.ru
Bulletin of Experimental Biology and Medicine
|September 11, 2001
Abstract:
We studied the incidence of chromosome aberrations in bone marrow cells and primary spermatocytes in various mouse strains. Experiments were performed on SAMP mice (accelerated aging), control SAMR mice, and long-living CBA and SHR mice. Experiments revealed a positive correlation between the age and the incidence of mutations in their somatic cells and gametes.
