Ultrastructure of synapses in cerebral cortex layer i in rats with low and high resistance to hypoxia
M M Svinov1, E I Zakharova, N S Kositsyn
1Laboratory of Ultrastructural and Cytochemical Bases of Conditioned Reflex, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences. svinov@hotmail.ru
Abstract:
Quantitative analysis of synapses in layer I of the sensorimotor cortex in rats with low resistance to hypoxia revealed pronounced changes in the number of synaptic vesicles docked at the presynaptic membrane in active synaptic zones under conditions of acute hypobaric hypoxia. In high-resistant animals the number of docked synaptic vesicles under these conditions remained unchanged. In was hypothesized that high sensitivity to hypoxia in low-resistant rats is determined by high reactivity of the synaptic transmission system.
