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Updated: Aug 7, 2026

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Published on: December 30, 2016
In vivo hyperpolarized 129Xe NMR spectroscopy in tumors
J Wolber1, D J McIntyre, L M Rodrigues
1CRC Clinical Magnetic Resonance Research Group and Physics Department, The Institute of Cancer Research, The Royal Marsden NHS Trust, Button, Surrey, UK.
Abstract:
The first in vivo hyperpolarized 129Xe NMR study in experimental tumors is presented. Hyperpolarized 129Xe was dissolved in solutions, and was injected intratumorally in GH-3 prolactinomas in rats and RIF-1 fibrosarcomas in mice. The 129Xe NMR spectra and apparent spin-lattice relaxation times in the two tumor types present characteristic differences. These differences are discussed in terms of xenon exchange between the carrier medium and the tissue compartments.

