[Effect of Kupffer cell stimulation by lipopolysaccharides on hepatocyte nuclei]

Metabolism of colloid gold labelled high and low density lipoproteins (LP) in the liver is related to receptor endocytosis in sinusoidal cells. In endotheliocytes, LP are carried to Disse's space primarily in endosomas, in macrophages--as a part of secondary lysosomas. The former variant of transcytosis may be unrelated to structural LP changes while the latter may be associated with their enzymic modification. LP endocytosis enhances in response to stimulation of macrophages with lipopolysaccharides, especially as concerns high density LP of subclass 3 (HDLP-3). In these conditions, hepatic sinusoidal cell uptake of LDLP and HDLP-3 together with glucocorticoids activates nuclear apparatus of hepatocytes, i.e. creates conditions for intensive protein synthesis.