Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secretory Phase01:19

Secretory Phase

2.3K
The secretory phase of the menstrual cycle, spanning from day 14 to 28 in a typical 28-day cycle, is a period of significant physiological changes in the female reproductive system. This phase commences immediately after ovulation and is characterized by the preparation of the endometrium for potential embryo implantation.
Following ovulation, the corpus luteum, a temporary endocrine structure, produces progesterone and estrogens. These hormones stimulate the growth and coiling of endometrial...
2.3K
Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

7.2K
Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
7.2K
Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

7.0K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
7.0K
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

9.6K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
9.6K
Hypertension I: Introduction01:28

Hypertension I: Introduction

957
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
957
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

1.0K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genes representing the stress-dependent component in arterial hypertension development.

Vavilovskii zhurnal genetiki i selektsii·2026
Same author

Features of Biochemical and Hematological Parameters and Chromosomal Disorders in Lymphocytes of Aging Primates of the Kurchatovsky Complex of Medical Primatology.

Doklady. Biochemistry and biophysics·2026
Same author

FlyDEGdb knowledge base on differentially expressed genes of Drosophila melanogaster, a model object in biomedicine.

Vavilovskii zhurnal genetiki i selektsii·2026
Same author

[Restraint Stress-Induced Expression of Fos and Several Related Genes in the Hypothalamus of Hypertensive ISIAH Rats].

Molekuliarnaia biologiia·2024
Same author

RatDEGdb: a knowledge base of differentially expressed genes in the rat as a model object in biomedical research.

Vavilovskii zhurnal genetiki i selektsii·2024
Same author

Metabolic profile of blood serum in experimental arterial hypertension.

Vavilovskii zhurnal genetiki i selektsii·2023

Related Experiment Video

Updated: Feb 11, 2026

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

7.7K

[SECRETORY ACTIVITY OF ATRIAL CARDIOMYOCYTES IN NORMOTENSIVE AND HYPERTENSIVE RATS DURING STRESS].

V F Maksimov, I M Korostyshevskaya, N S Rudenko

    Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova
    |April 20, 2018
    PubMed
    Summary
    This summary is machine-generated.

    This study reveals that inherited arterial hypertension intensifies cardiac hormone production in rats. Stress significantly reduces atrial natriuretic peptide (ANP) levels, highlighting its role in hemodynamic regulation and stress response.

    More Related Videos

    Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
    08:31

    Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

    Published on: July 26, 2018

    10.9K
    Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
    11:33

    Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

    Published on: March 12, 2013

    13.8K

    Related Experiment Videos

    Last Updated: Feb 11, 2026

    Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
    08:34

    Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

    Published on: November 18, 2018

    7.7K
    Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
    08:31

    Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

    Published on: July 26, 2018

    10.9K
    Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
    11:33

    Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes

    Published on: March 12, 2013

    13.8K

    Area of Science:

    • Cardiovascular Physiology
    • Endocrinology
    • Cell Biology

    Background:

    • Inherited arterial hypertension is a significant health concern.
    • Atrial myoendocrine cells produce cardiac hormones crucial for blood pressure regulation.
    • Understanding the role of atrial natriuretic peptide (ANP) in hypertension and stress is vital.

    Purpose of the Study:

    • To conduct an ultrastructural and immune-enzymatic evaluation of atrial myoendocrine cell secretory activity.
    • To compare secretory activity in normotensive WAG rats and rats with inherited hypertension (ISIAH rats).
    • To investigate the effects of subchronic restraint stress on ANP synthesis, storage, and secretion.

    Main Methods:

    • Ultrastructural analysis of atrial myoendocrine cells.
    • Immune-enzymatic evaluation of secretory activity.
    • Measurement of blood atrial natriuretic peptide (ANP) concentration.
    • Application of subchronic restraint stress model.

    Main Results:

    • Hypertensive rats showed intensified cardiac hormone synthesis, storage, and secretion under basal conditions.
    • Blood ANP concentration was significantly higher in hypertensive rats compared to controls.
    • Restraint stress led to decreased ANP release and accumulation in secretory granules in all rats, with a 6-fold reduction in blood ANP.

    Conclusions:

    • Cardiac natriuretic peptides play a compensatory role in inherited arterial hypertension.
    • ANP is involved in the body's response to stress.
    • These findings elucidate the complex interplay between cardiac hormones, hypertension, and stress responses.