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Genes representing the stress-dependent component in arterial hypertension development.

D Yu Oshchepkov1, Yu V Makovka1, I V Chadaeva2

  • 1Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Vavilovskii Zhurnal Genetiki I Selektsii
|February 20, 2026
PubMed
Summary

Chronic psychoemotional stress contributes to hypertension by altering gene expression. This study reveals shared molecular mechanisms between stress and hypertension, identifying potential diagnostic markers for stress.

Keywords:
principal component analysisarterial hypertensionbiomedical modeldifferentially expressed gene (DEG)humanratstress

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cardiovascular Research

Background:

  • Hypertension is a major cardiovascular disease risk factor.
  • Chronic psychoemotional stress is a key cause of hypertension.
  • Animal models, like the ISIAH and WAG rats, are crucial for studying hypertension's molecular mechanisms.

Purpose of the Study:

  • To investigate the shared molecular mechanisms between psychoemotional stress and hypertension.
  • To identify potential diagnostic markers for psychoemotional stress.

Main Methods:

  • Utilized the RatDEGdb database for hypothalamic gene expression in hypertensive and normotensive rats under stress.
  • Annotated rat genes with human orthologs using differential gene expression (DEG) data from hypertensive patients.
  • Applied principal component analysis (PCA) to orthologous DEGs from rats and humans.

Main Results:

  • PCA revealed that two components explained 64% and 33% of gene expression variance, linking stress response in rats to human hypertension.
  • A significant correlation between stress-induced gene downregulation and hypertension suggests shared molecular pathways.
  • Downregulation of genes related to plasma membrane and extracellular matrix interactions, mediated by the SMARCA4 transcription factor, is implicated in stress-induced hypertension.

Conclusions:

  • Psychoemotional stress and hypertension share common molecular mechanisms, particularly involving stress-induced gene downregulation.
  • The SMARCA4 transcription factor may mediate epigenetic modifications contributing to hypertension under chronic stress.
  • Peripheral blood markers for diagnosing psychoemotional stress are proposed, offering potential diagnostic tools.