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TBARS and cardiovascular disease in a population-based sample.
E F Schisterman1, D Faraggi, R Browne
1Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, New York, USA. Enrique.Schisterman@cshs.org
Journal of Cardiovascular Risk
|September 12, 2001
Summary
Elevated thiobarbituric acid reaction substances (TBARS), a marker of oxidative stress, are linked to increased cardiovascular disease (CVD) risk. However, this association diminishes when glucose levels are considered.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Oxidative Stress Research
Background:
- Oxygen radicals are implicated in diseases like atherosclerosis.
- Thiobarbituric acid reaction substances (TBARS) are proposed biomarkers for oxidative stress.
- Previous studies lacked strong evidence linking TBARS to atherosclerosis prevalence.
Purpose of the Study:
- To investigate the relationship between TBARS and cardiovascular disease (CVD).
- To assess TBARS as a potential biomarker for CVD risk.
Main Methods:
- Cross-sectional study of a random sample of white men and women.
- Logistic regression analysis to estimate risk associated with high TBARS levels.
- Receiver Operating Characteristic (ROC) curve analysis to evaluate TBARS discriminating power.
Main Results:
- Adjusted TBARS levels were significantly higher in individuals with prevalent CVD (OR=1.73).
- Correcting for measurement error increased the odds ratio (OR=1.93).
- ROC analysis showed moderate discriminating power for TBARS (AUC=0.69), improving to 0.80 after measurement error correction.
Conclusions:
- Elevated TBARS levels are associated with an increased prevalence of CVD.
- The association between TBARS and CVD risk was not significant after adjusting for glucose levels.