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TBARS and cardiovascular disease in a population-based sample.

E F Schisterman1, D Faraggi, R Browne

  • 1Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, University at Buffalo, New York, USA. Enrique.Schisterman@cshs.org

Journal of Cardiovascular Risk
|September 12, 2001
PubMed
Summary

Elevated thiobarbituric acid reaction substances (TBARS), a marker of oxidative stress, are linked to increased cardiovascular disease (CVD) risk. However, this association diminishes when glucose levels are considered.

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Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Oxidative Stress Research

Background:

  • Oxygen radicals are implicated in diseases like atherosclerosis.
  • Thiobarbituric acid reaction substances (TBARS) are proposed biomarkers for oxidative stress.
  • Previous studies lacked strong evidence linking TBARS to atherosclerosis prevalence.

Purpose of the Study:

  • To investigate the relationship between TBARS and cardiovascular disease (CVD).
  • To assess TBARS as a potential biomarker for CVD risk.

Main Methods:

  • Cross-sectional study of a random sample of white men and women.
  • Logistic regression analysis to estimate risk associated with high TBARS levels.
  • Receiver Operating Characteristic (ROC) curve analysis to evaluate TBARS discriminating power.

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Main Results:

  • Adjusted TBARS levels were significantly higher in individuals with prevalent CVD (OR=1.73).
  • Correcting for measurement error increased the odds ratio (OR=1.93).
  • ROC analysis showed moderate discriminating power for TBARS (AUC=0.69), improving to 0.80 after measurement error correction.

Conclusions:

  • Elevated TBARS levels are associated with an increased prevalence of CVD.
  • The association between TBARS and CVD risk was not significant after adjusting for glucose levels.