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Influence of therapeutic concentrations of phenylbutazone on granulocyte function
Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology
|April 1, 1975
Abstract:
The influence of therapeutic concentrations of phenylbutazone on human granulocyte function has been examined using a method which facilitates a precise in vitro evaluation of the phagocytic and bactericidal activities of polymorphonuclear leucocytes. Phenylbutazone caused a marked reduction in intracellular killing of bacteria by the granulocytes. Whether this inhibition of granulocyte function also takes place in vivo resulting in enhanced susceptibility to infection, remains unknown.