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Published on: November 5, 2019
[Treatment of acute bacterial meningitis]
S Skrede1, H Sjursen, C O Solberg
1Infeksjonsmedisinsk seksjon Medisinsk avdeling Haukeland Sykehus 5021 Bergen. steinar.skrede@haukeland.no
Background:
Acute bacterial meningitis requires immediate antimicrobial therapy.
Materials And Methods:
Guidelines to antimicrobial treatment of children and adults with acute bacterial meningitis are presented.
Results:
The most common agents causing acute bacterial meningitis are Streptococcus agalactiae in children less than one month of age, and Streptococcus pneumoniae and Neisseria meningitidis in individuals more than one month of age. If the causative bacterial agent is not known, children below one month of age should be given ampicillin and gentamicin, whereas older children and adults should be given benzylpenicillin in combination with either cefotaxime or ceftriaxone. We suggest treatment with specific antibiotic regimens in cases of known aetiology.
Insights
Immediate antimicrobial therapy is crucial for acute bacterial meningitis. Guidelines recommend specific antibiotics based on age and suspected pathogens like Streptococcus pneumoniae and Neisseria meningitidis.
Area of Science:
- Infectious Diseases
- Microbiology
- Pediatrics
Context:
- Acute bacterial meningitis necessitates prompt antimicrobial intervention.
- Established guidelines inform the treatment of pediatric and adult bacterial meningitis.
Purpose:
- To present evidence-based guidelines for the antimicrobial treatment of acute bacterial meningitis in children and adults.
- To outline recommended antibiotic regimens based on patient age and common causative pathogens.
Summary:
- Common bacterial agents include Streptococcus agalactiae (infants <1 month), Streptococcus pneumoniae, and Neisseria meningitidis (>1 month).
- Empirical treatment for neonates involves ampicillin and gentamicin; older children and adults receive benzylpenicillin with cefotaxime or ceftriaxone.
- Specific antibiotic choices are recommended when the etiological agent is identified.
Impact:
- Facilitates timely and appropriate antimicrobial selection for acute bacterial meningitis.
- Aims to improve patient outcomes by guiding effective treatment strategies.
- Supports clinicians in managing a critical pediatric and adult infectious disease.
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