Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein repeats: structures, functions, and evolution.

M A Andrade1, C Perez-Iratxeta, C P Ponting

  • 1European Molecular Biology Laboratory, Meyerhofstr. 1, Heidelberg, 69012, Germany.

Journal of Structural Biology
|September 12, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of <i>in ovo</i> injection of 25(OH)D<sub>3</sub> in combination with Marek's disease vaccine on hatchability, performance and bone health of broilers.

British poultry science·2025
Same author

Acute effect of passive cycle-ergometry and functional electrical stimulation on nitrosative stress and inflammatory cytokines in mechanically ventilated critically ill patients: a randomized controlled trial.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2020
Same author

Resolving the fibrotic niche of human liver cirrhosis at single-cell level.

Nature·2019
Same author

ELIXIR-UK role in bioinformatics training at the national level and across ELIXIR.

F1000Research·2017
Same author

An isolate of the nematophagous fungus Monacrosporium thaumasium for the control of cattle trichostrongyles in south-eastern Brazil.

Journal of helminthology·2014
Same author

A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing.

Molecular psychiatry·2012
Same journal

Ultrastructural evidence of autophagy-related processes and mitochondrial remodeling in the myxozoan parasite Henneguya piaractus.

Journal of structural biology·2026
Same journal

Architecture and dynamics of a supramolecular oxygen transport system in human homogentisate 1,2-Dioxygenase.

Journal of structural biology·2026
Same journal

Connecting pathways between mineralized fibrocartilage and bone at the Achilles tendon insertion.

Journal of structural biology·2026
Same journal

Structural and functional characterization of thermostable EstS1 esterase for BHET degradation.

Journal of structural biology·2026
Same journal

Following the white rabbit: multiscale 2D3D correlative imaging of bone structure.

Journal of structural biology·2026
Same journal

The mantis shrimp eye imaged in 3D using 4th generation synchrotron multiscale phase contrast tomography.

Journal of structural biology·2026
See all related articles

Protein internal repeats enhance evolutionary potential by increasing binding surfaces. Detecting these diverse, short repeats is challenging, yet crucial for understanding their complex origins and functions.

Area of Science:

  • Molecular Biology
  • Evolutionary Biology
  • Structural Biology

Background:

  • Internal protein repeats are common evolutionary strategies.
  • These repeats form regular secondary structures and diverse 3D assemblies.
  • Repetition enhances binding surface area, improving evolutionary prospects.

Purpose of the Study:

  • To review the evolution and detection of internal protein repeats.
  • To explore the challenges in identifying divergent and short sequence repeats.
  • To discuss the evolutionary conundrum of multiple interdependent repeats arising from single ancestors.

Main Methods:

  • Review of existing literature on protein repeat structures and functions.
  • Analysis of six prolific repeat types: beta-propellers, beta-trefoils, tetratricopeptide, ankyrin, armadillo/HEAT, and leucine-rich repeats.

Related Experiment Videos

  • Discussion of evolutionary mechanisms and sequence conservation.

    • Main Results:

    • Internal repeats offer expanded binding surfaces, facilitating functional diversification.
    • Sequence divergence and short repeat lengths complicate detection.
    • Strong structural and functional interdependencies suggest complex evolutionary pathways.

    Conclusions:

    • Protein internal repeats are key to evolutionary adaptation and functional complexity.
    • Developing robust methods for repeat detection is essential.
    • Understanding the evolution of multirepeat systems provides insights into protein evolution.