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Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...

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Related Experiment Video

Updated: Jul 12, 2026

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
09:40

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

Signaling pathways controlling cell polarity and chemotaxis.

C Y Chung1, S Funamoto, R A Firtel

  • 1Section of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0634, USA.

Trends in Biochemical Sciences
|September 12, 2001
PubMed
Summary

Cell polarity and directional signaling are crucial for biological processes like chemotaxis. Phosphoinositide 3-kinase is key in regulating cell polarity and chemotaxis, as detailed in this review.

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Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
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Area of Science:

  • Cellular biology
  • Biochemistry

Background:

  • Chemotaxis, a vital biological process involving directional cell movement, necessitates robust cell polarity and directional signal responsiveness.
  • Recent research using Dictyostelium cells and mammalian leukocytes has illuminated the complex biochemical and molecular mechanisms governing chemotaxis.

Purpose of the Study:

  • To review the current understanding of the pathways controlling chemotaxis.
  • To highlight the central role of Phosphoinositide 3-kinase in cell polarity and chemotaxis.

Main Methods:

  • This review synthesizes findings from recent studies on chemotaxis.
  • Focuses on the molecular pathways involving Phosphoinositide 3-kinase.

Main Results:

  • Phosphoinositide 3-kinase is pivotal in establishing and maintaining cell polarity.
  • It regulates downstream effectors essential for cell polarity and chemotaxis.

Conclusions:

  • Phosphoinositide 3-kinase is a key regulator in the molecular pathways of chemotaxis.
  • Understanding these pathways is crucial for comprehending cell movement and polarity in biological systems.