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[Hemorrhagic syndrome during high-dose ampicillin treatment]

M Dugnani1, G Rizzo, P L Garavelli

  • 1Strutture Complesse di Medicina Interna II, Azienda Ospedaliera Maggiore della Carità, Novara.

Recenti Progressi in Medicina
|September 13, 2001
PubMed

Insights

High doses of beta-lactam antibiotics, like ampicillin, can cause bleeding by affecting prothrombin formation. This case highlights a hemorrhagic syndrome in a woman treated for Listeria meningitis.

Area of Science:

  • Pharmacology
  • Hematology
  • Infectious Diseases

Background:

  • Beta-lactam antibiotics, particularly cephalosporins, are known to potentially cause bleeding disorders.
  • Impairment of prothrombin formation is a mechanism linked to antibiotic-induced coagulopathy.

Observation:

  • A 63-year-old female patient developed a hemorrhagic syndrome.
  • The patient was undergoing treatment with high-dose ampicillin for Listeria monocytogenes meningitis.

Findings:

  • High-dose ampicillin therapy was associated with the observed hemorrhagic syndrome.
  • The case suggests a link between ampicillin and impaired prothrombin formation leading to bleeding.

Implications:

  • Clinicians should be aware of the risk of bleeding complications with high-dose beta-lactam therapy.
  • Monitoring coagulation parameters may be warranted in patients receiving prolonged high-dose ampicillin treatment.
  • This case underscores the importance of considering drug-induced coagulopathy in patients presenting with unexplained bleeding.

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