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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Developing a synagis clinic for respiratory syncytial virus prophylaxis
S Coffman1, J Peck, C S Rasmussen
1Sierra Health Services, Las Vegas, N.V. USA. scoffman@sierrahealth.com
MCN. the American Journal of Maternal Child Nursing
|September 13, 2001
Summary
Palivizumab (Synagis) injections prevent Respiratory Syncytial Virus (RSV) in high-risk infants. A specialized clinic reduced RSV hospitalizations and days hospitalized in these vulnerable children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Respiratory Syncytial Virus (RSV) poses significant risks to premature infants and children with chronic lung disease.
- Palivizumab (Synagis), a monoclonal antibody, is a key preventative measure against RSV infection in high-risk infants.
- Effective delivery of prophylaxis requires coordinated healthcare efforts.
Purpose of the Study:
- To describe the implementation and outcomes of a nurse-run ambulatory clinic for RSV prophylaxis.
- To evaluate the effectiveness of monthly palivizumab injections in a high-risk pediatric population.
- To assess the impact of coordinated care on RSV-related hospitalizations.
Main Methods:
- A nurse-managed ambulatory clinic administered monthly palivizumab injections over a 5-month RSV season.
- Coordination with community neonatal intensive care units was integral to patient recruitment and follow-up.
- Clinic outcomes were compared to published literature for similar patient cohorts.
Main Results:
- The clinic successfully provided RSV prophylaxis to 24 high-risk infants and their families each year for 2 years.
- RSV-related hospitalizations were reduced in the patient population served by the clinic.
- The duration of hospitalization for RSV-related events was also decreased.
Conclusions:
- A dedicated, nurse-run clinic model can effectively deliver RSV prophylaxis to high-risk infants.
- Inter-agency coordination is crucial for successful implementation of preventative health programs.
- This model demonstrates a positive impact on reducing the burden of RSV in vulnerable pediatric populations.
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