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Updated: Jul 14, 2026

Laboratory Techniques Used to Maintain and Differentiate Biotypes of Vibrio cholerae Clinical and Environmental Isolates
Published on: May 30, 2017
Environmental signals controlling production of hemagglutinin/protease in Vibrio cholerae
J A Benitez1, A J Silva, R A Finkelstein
1California State University College of Science and Mathematics, Fresno, California 93740-8034, USA. jbenitez@csufresno.edu
Abstract:
Vibrio cholerae hemagglutinin/protease (Hap) was induced upon nutrient limitation and strongly repressed by glucose. Hap was not produced in a mutant defective in the cyclic AMP (cAMP) receptor protein, suggesting that intracellular cAMP levels mediate Hap expression. No difference was found in Hap production between an rpoS deletion mutant and its isogenic wild-type precursor, indicating that the alternate sigma(s) factor is not essential for Hap expression. Based on these and previous results, we discuss the role of Hap in the pathogenesis of cholera.
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