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Updated: Aug 2, 2026
An In Vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal (RHE) Model
Published on: July 13, 2009
[Value of delayed skin test in elderly patients]
A Castillo Méndez1, A Hernández Castillo, A J Gravalosa Cruz
1Servicio de Inmunoalergia, Hospital General Docente Salvador Allende, La Habana, Cuba.
Background:
Retarded cutaneous hypersensitivity to several antigens has been studied in human of different ages and in people older than 60 years a diminishment in response to tests measuring retarded hypersensitivity has been observed.
Objective:
To determine the pattern of response to tests of retarded hypersensitivity in an apparently healthy sample of Cuban population resident at La Habana City, by application of a group of cutaneous tests with national antigens.
Material And Methods:
Intradermal tests were applied to 87 subjects (69 women and 18 men) between 60 and 89 years old, without frequent infection antecedents. All subjects were submitted to clinical history and analysis in order to discard diseases that may alter the study proposal. Response grade was determined by summing media of induration diameters, which was denominated total media punctuation.
Results:
In all age groups total media punctuation was lightly higher in women, in both control and study groups, excepting age group of 80-89 years.
Conclusion:
By virtue of there are few indicators of health for old people, the group of tests proposed in this article may be a good predictive indicator of morbidity and mortality in old patients.
